New drug can fight rectal cancer stem cells in mice
The recently published "Nature-Medicine" magazine reported a therapeutic drug that can fight stem cells of rectal cancer in mice. Cancer stem cells are considered to be one of the causes of drug resistance and tumor recurrence. This new discovery may help to develop more effective cancer treatments.
Cancer is composed of various types of cell populations, including a small but stubborn stem cell fragment that can reproduce and regenerate itself and promote the differentiation of more tumor cells. To completely eradicate cancer, eradicating cancer stem cell populations is a necessary way; however, the unique properties of these stem cells make them resistant to many cancer treatments, which makes them still difficult to deal with aims.
John Dick et al. Found that BMI-1, a protein in mice, can affect gene expression and is also a key factor for the self-regeneration and tumor formation of stem cells in human rectal cell lines and patients with rectal cancer. The researchers developed a drug that can reduce BMI-1 levels, which can block the function of cancer stem cells in mice and the growth of primary human rectal cancer. This study shows that inhibiting BMI-1 may help improve cancer treatments and provide sustained anti-tumor effects.
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