Mainly manifested in: the level of product standards, physical quality is poor, the structure is irrational, product quality and low added value, so that the contribution of pharmaceutical glass to the pharmaceutical economy is significantly lower than developed countries. Therefore, medicinal glass production should be brought into line with the international level as soon as possible from the following aspects. At the standard level, it is necessary to actively adopt international standards, comprehensively improve the level of product quality, and establish and perfect the standardization system of pharmaceutical glass bottles in China as soon as possible. In terms of type, the international standard ISO12775-1997 clearly states that there are mainly three types of medicinal glass: 3.3 borosilicate glass, international neutral glass, and soda-lime glass. Due to the limitation of our country's technological level, we have not been able to produce international neutral glass with strong water resistance, acid resistance, and alkali resistance on a large scale. We should gradually transition in the future to focus on the development of international neutral glass. In terms of material properties, the international neutral glass and 3.3 borosilicate glass particles can reach a level of water resistance. Although most of the low borosilicate glass particles in China have a water resistance rating of 1 and some of them have a rating of 2, the amount of alkaline precipitation from microscopic views is several times larger than that of international neutral glass.
In terms of the limit of harmful substances, there are regulations on the amount of As, Sb, Pb, and Cd in glass that are released internationally. As the medical glass bottle with the highest requirements for safety and health, China should limit the amount of harmful elements released in order to ensure the safety of people's drug use. The test method should be quantitatively and quantitatively developed from the original qualitative, semi-quantitative and quantitative. Such as the internal surface water resistance, in the past with the methyl red acidic solution discoloration method, now using the total amount of alkali titration method, the international still have to Na, K, Ca, respectively, quantitative determination.
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