Trehalose is a stable non-reducing disaccharide that is widely found in algae, bacteria, fungi, yeast, insects, and invertebrates. It is not only a storage sugar, but also an important product of stress metabolism, and it is a non-reducing sugar composed of special disaccharide molecules. It has very stable characteristics and can withstand harsh conditions such as high temperature, high cold, dryness and water loss. A special protective film is formed on the cell surface to effectively protect the biomolecular structure from being destroyed, thereby maintaining the life process and biological characteristics of the living body. It can be widely used in various industries such as biologics, medicine, food, cosmetics and agricultural science.
In foods and medicines, it can very effectively protect biofilms and biological macromolecules, and prevent cells from being damaged by drying, freezing and osmotic pressure changes; it can effectively protect DNA from damage caused by radiation; Plasma protein as a stabilizer for biological products and vaccines; used in cosmetics, has a moisturizing function; used in food preservation, food sweeteners, can replace high-calorie sucrose, especially suitable for diabetics; used in children's food, such as candy, Chocolate sweetener can effectively reduce the incidence of dental caries in children.
It is understood that so far, the only companies that have produced trehalose on a large scale globally are Japan's Linyuan Chemical Company and Nanning Zhongnuo Bioengineering Co., Ltd. in Nanning, Guangxi, China. At present, the Beijing Technology Exchange Center has completed all small-scale trial production processes using corn steep starch as raw materials and the enzymatic preparation of trehalose, and has already met the pilot test conditions. During the production process, the fermentation rate and raw material conversion rate are high, which also greatly reduces the cost.
At present, there is a large demand for trehalose in the international market. It is estimated that the annual demand will reach more than 150,000 tons in the next few years, while the current comprehensive productivity of Shanghai International Trehalose is only about 80,000 tons per year. With rapid expansion, the demand for trehalose will also increase dramatically. In the past, trehalose used in the country was basically imported from Japan, so there is still a lot of room for using enzyme method to produce trehalose products instead of imported products, and the strains used to produce trehalose using corn starch as raw materials are non-genetic engineering bacteria The product is a non-genetically engineered product. There are 20 million newborns in China every year, which require 1 billion vaccines and trehalose as a stabilizer. The annual output value of this alone can reach 80 million yuan.
With regard to the preservation of food, agricultural products and marine products, except for the low production levels of some enterprises that do not use trehalose, the market demand in 2002 has reached more than 2500t. By 2005, China ’s annual demand for trehalose will reach 10 10,000 t or more. Therefore, if the sales of trehalose are positioned in the popularization of food preservation and cosmetics industry, the benefits are considerable. It is estimated that a production plant with an annual output of 100 tons of trehalose requires 3 million yuan in equipment investment, a direct raw material cost of about 7,000 yuan / t, a product market price of 79,000 yuan / t, and an annual profit of 4.8 million yuan.
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