What is the difference between using fetal bovine serum and calf serum?
If fetal bovine serum (FBS) and calf serum are both available, many biocell growers tend to prefer fetal bovine serum. But why is that? What exactly makes FBS different from calf serum? Let’s take a closer look at the differences and why FBS is often the preferred choice in cell culture.
First, the source of the serum differs significantly. Fetal bovine serum is collected from fetuses that are obtained by cardiac puncture during the slaughter of pregnant cows. On the other hand, calf serum is taken from calves that are just a few days old, typically within the first 10 to 14 days of life. This difference in origin plays a key role in the quality and characteristics of the serum.
Second, the composition and concentration of active components vary between the two. FBS contains higher levels of growth factors, adhesion-promoting substances, and hormones, making it more suitable for supporting the growth of sensitive or difficult-to-culture cells. Calf serum, while still effective, has a slightly different profile and may not be as potent for certain types of cell lines. The concentration used also varies depending on the cell type—usually between 5% and 10%, with some specialized cases requiring up to 20%.
Third, when considering overall quality, fetal bovine serum tends to be more consistent and reliable. Since fetal calves live in a relatively sterile environment, their serum is less likely to be contaminated compared to that of older calves, which may have been exposed to various environmental factors. As long as the production process is strictly controlled and standardized, FBS can offer superior performance and stability. Shanghai Hengyuan Bio recommends choosing the appropriate serum based on ATCC guidelines and specific experimental requirements. For most standard cell cultures, even domestic FBS can provide excellent results.
At Shanghai Hengyuan Bio, we ensure 100% quality assurance for all our serum products, backed by a strong reputation and consistent performance. Whether you're working in a research lab or a commercial setting, our serum is an ideal choice. If you need further assistance or have questions about serum selection, feel free to reach out to our sales team for personalized guidance.
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