Scientists "laborate the kidney" to transplant mice
American researchers say that a mouse kidney "bred" in the laboratory has been transplanted into a mouse and started to produce urine.
The BBC reported on April 14 that a research article published in the journal Nature-Medical said that although "transforming kidneys" is not as effective as "natural kidneys", researchers believe that this field has broad prospects. As expected, the researchers stripped the cells from an aging kidney, leaving a honeycomb-shaped "scaffold", and then moved into the cells of the transplanted patient.
Researchers at the Massachusetts General Hospital have completed the first step to remove cells from a mouse kidney. For the next 12 days, they placed the kidney in a special oven that mimics the environment inside the mouse. When the "Renovated Kidney" was tested in the laboratory, the urine production efficiency reached 23% of the natural kidney. However, after implantation in a mouse, this index fell to 5%.
Harald Ott, head of the research team, is satisfied with the results of the study, saying that if the "transformed kidney" has a 10% to 15% efficacy of natural kidney, patients will no longer need hemodialysis.
The researchers say that the “remodeling kidney†technique has two main advantages: “remodeling the kidney†matches the patient, and the patient does not need to take anti-rejection drugs for life after receiving the transplant; this will greatly increase the number of transplantable organs. Transplantable organs cannot be transplanted because they do not match the patient, but they can be transplanted after undergoing "remodeling".
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